Article one states that the gene codes for an enzyme that shows significant similarities to the alpha/beta hydrolase fold family though function is unknown. Gene is imprinted and expression was confirmed to the paternal derived allele. However, in blood lymphocytes biallelic expression was shown. Different expression patterns in different tissues. The human peg1 gene spans a genomic region of aprox 13 kb. A 620 bp CpG-island was found in the 5-prime region, the island extends from the plausible promotor to the first intron. Regulation is thought to be achieved through metylation.
Article two: Focuses on PEG1 isoform 2, which was thought to be biallically expressed (non-imprinted) in ceveral non-placental organs producing a shorter version of the MEST protein. Knockout mice show that the gene in mouse regulates placental and fetal growth (causes growth restrictions). The article also shows different types of imprinting in human placenta, both DNA methylation and allele-specific mRNA expression.
Article three is about a similar protein found in zeebrafish. It discusses the linkage with another gene, copg2 and its occurance in larvae.
Article four states that the human chromosomal region were peg1/mest is expressed is 7q21-qtr and human maternal uniparental disonomy (upd 7). It causes apparent growth deficiencies and slight morphological abnormalities.
